窦迎港,党艳艳

• 1:石河子大学化学化工学院/化工绿色过程省部共建国家重点实验室培育基地

摘要(Abstract)：

叶黄素对光、热敏感，导致其稳定性差，为解决此问题，对叶黄素进行微胶囊化处理。文章以叶黄素为芯材，玉米醇溶蛋白、葡聚糖为壁材，采用反溶剂沉淀法对叶黄素进行包埋，在单因素试验的基础上采用响应面法优化叶黄素微胶囊的制备工艺，对其进行表征并测定其贮藏稳定性和抗氧化性。结果表明，叶黄素微胶囊的最佳制备条件为乙醇浓度84%、溶剂与反溶剂体积比1∶2、反应温度39℃、玉米醇溶蛋白浓度4.0 mg/mL、葡聚糖浓度1.0 mg/mL,此时包埋率为90.53%,载药率为8.23%。包埋后叶黄素的饱和溶出度提高了4.84倍，贮藏6周后，叶黄素微胶囊在光照条件下的保留率高于叶黄素35.20%,在25℃下叶黄素微胶囊的保留率高于叶黄素23.11%,在4℃下叶黄素微胶囊的保留率高于叶黄素16.31%,在-20℃下叶黄素微胶囊的保留率仅下降1.91%。叶黄素微胶囊对DPPH、ABTS~+自由基的抗氧化活性高于未包埋的叶黄素。该研究结果可为叶黄素微胶囊作为新型添加剂在工业领域的应用提供理论参考。

关键词(KeyWords)： 叶黄素微胶囊;响应面法;结构表征;稳定性;抗氧化性

Abstract:

Keywords:

基金项目(Foundation): 新疆生产建设兵团指导性科技计划项目(2022ZD066)

作者(Author): 窦迎港,党艳艳

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