乳酸链球菌素(Nisin)的生物合成研究进展Research Progress on Biosynthesis of Nisin
杨勇,赵阳娟,刘希,童星
摘要(Abstract)：
文章对天然防腐剂——乳酸链球菌素(Nisin)的生物合成进展进行了综述。对乳酸链球菌素的化学结构以及特点、结构与功能的关系、生物合成基因簇、翻译后修饰、生物合成调控水平等在化学、生物学等机理方面进行了介绍，希望国内广大科研工作者由此而得到启发，在发现新的细菌素方面提供一些思路。
关键词(KeyWords)： 乳酸链球菌素;天然防腐剂;生物合成;羊毛硫菌素;翻译后修饰
基金项目(Foundation): 粤佛联合基金项目(2019B1515120053);; 佛山市核心技术攻关项目(1920001000824)
作者(Author): 杨勇,赵阳娟,刘希,童星
参考文献(References)：
- [1]张益卓，赵长青，赵兴秀，等.乳酸链球菌素在延长猪肉干保藏期中的应用[J].中国调味品，2022,47(3):44-48.
- [2]朱燕莉，王正莉，王卫，等.天然食品防腐剂的抑菌机理研究进展[J].中国调味品，2021,46(9):176-180.
- [3]张鑫，李迎秋.两种天然防腐剂对单增李斯特菌抑菌性的研究[J].中国调味品，2021,46(2):37-39,45.
- [4]王双童，张志毅，李迎秋.两种天然防腐剂对单增李斯特氏菌抑菌机制的研究[J].中国调味品，2021,45(10):14-16.
- [5]张金磊，陈兴煌.乳酸菌发酵液在食品贮藏保鲜中的应用研究进展[J].中国调味品，2020,45(10):158-162.
- [6]李东，孙健，彭沈军.天然生物食品防腐剂乳酸链球菌素的研究进展[J].食品与发酵工业，1995(4):58-61.
- [7]SABLON E,CONTRERAS B,VANDAMME E.Antimicrobial peptides of lactic acid bacteria:mode of action,genetics and biosynthesis[J].Advances in Biochemical Engineering/Biotechnology,2000,68:21-60.
- [8]FIELD D,COTTER P,ROSS R P,et al.Bioengineering of the model lantibiotic nisin[J].Bioengineered,2015,6(4):187-192.
- [9]VAN DER DONK W A.Rings,radicals,and regeneration:the early years of a bioorganic laboratory[J].The Journal of Organic Chemistry,2006,71(26):9561-9571.
- [10]SIEZEN R J,KUIPERS O P,VOS W M.Comparison of lantibiotic gene clusters and encoded proteins[J].Antonie van Leeuwenhoek,1996,69(2):171-184.
- [11]BIERBAUM G,SAHL H G.Lantibiotics:mode of action,biosynthesis and bioengineering[J].Current Pharmaceutical Biotechnology,2009,10(1):2-18.
- [12]MCAULIFFE O,ROSS R P,HILL C.Lantibiotics:structure,biosynthesis and mode of action[J].FEMS Microbiology Reviews,2001,25(3):285-308.
- [13]LUBELSKI J,RINK R,KHUSAINOV R,et al.Biosynthesis,immunity,regulation,mode of action and engineering of the model lantibiotic nisin[J].Cellular and Molecular Life Sciences,2008,65(3):455-476.
- [14]ENTIAN K D,VOS W M.Genetics of subtilin and nisin biosyntheses:biosynthesis of lantibiotics[J].Antonie van Leeuwenhoek,1996,69(2):109-117.
- [15]KLEEREBEZEM M.Quorum sensing control of lantibiotic production;nisin and subtilin autoregulate their own biosynthesis[J].Peptides,2004,25(9):1405-1414.
- [16]GUDER A,WIEDEMANN I,SAHL H G.Posttranslationally modified bacteriocins—the lantibiotics[J].Peptide Science,2000,55(1):62-73.
- [17]YU Y,ZHANG Q,VAN DER DONK W A.Insights into the evolution of lanthipeptide biosynthesis[J].Protein Science,2013,22(11):1478-1489.
- [18]PAG U,SAHL H G.Multiple activities in lantibiotics-models for the design of novel antibiotics?[J].Current Pharmaceutical Design,2002,8(9):815-833.
- [19]SHIN J M,GWAK J W,KAMARAJAN P,et al.Biomedical applications of nisin[J].Journal of Applied Microbiology,2016,120(6):1449-1465.
- [20]CHEIGH C I,PYUN Y R.Nisin biosynthesis and its properties[J].Biotechnology Letters,2005,27(21):1641-1648.