侯莎,吴昌正,童星

• 1:佛山市海天调味食品股份有限公司
• 2:广东海天创新技术有限公司

摘要(Abstract)：

米曲霉是酱油、黄豆酱等传统酿造调味品的主要生产菌株,具有悠久的应用历史。近年来,人们逐渐发现除了酿造功能之外,米曲霉还有丰富的次级代谢产物,其中不乏具有抑菌、抗氧化等功能的活性分子,在医药、美妆等领域具有极大应用潜力。但因为米曲霉次级代谢网络的复杂性,这些活性分子的产生规律和调控机制尚未被完全阐明,难以开发适用于工业场景的高产工程菌株,限制了米曲霉在工业领域的广泛应用。随着技术的进步和研究的深入,米曲霉次级代谢途径及其调控方式逐步被揭示和阐明,将会有效推动新功能化合物的进一步发掘以及高产工程菌株的选育和应用。文章综述了米曲霉次级代谢产物及分子调控的最新研究进展,并对这一领域的未来发展进行了展望。

关键词(KeyWords)： 米曲霉;次级代谢物;活性分子;调控机制;产量提升

Abstract:

Keywords:

基金项目(Foundation): 佛山市博士后科研基金(A-1906);; 佛山市核心技术攻关项目(1920001000824);; 广东省调味食品生物发酵先进技术企业重点实验室建设项目(2017B030302002)

作者(Author): 侯莎,吴昌正,童星

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