马瑛

• 1:安康学院农学与生命科学学院

摘要(Abstract)：

大蒜是一种常用的调味品,也是一种古老的预防和治疗疾病的民间药方。流行病学研究显示:心血管疾病的进展与大蒜的摄入量呈负相关。大量的体外研究和体内研究显示:大蒜能降低胆固醇和血脂水平,抑制血小板聚合,降低血压,防止血栓的形成,清除氧自由基等,从而达到预防和治疗心血管疾病的效果。

关键词(KeyWords)： 大蒜;心血管疾病;体内试验

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 马瑛

参考文献(References)：

• [1]Rahman K.Historical perspective on garlic and cardiovascular disease[J].J-Nutr.,2001,131(3):977-979.
• [2]闫淼淼,许真,徐蝉,等.大蒜功能成分研究进展[J].食品科学,2010,31(5):312-318.
• [3]Rahman K,Lowe G M.Garlic and cardiovascular disease:a critical review[J].J-Nutr.,2006,136(3):736-740.
• [4]Yeh Y Y,Liu L.Cholesterol-lowering effects of garlic extracts and organosulfur com pounds:human and animal studies[J].J-Nutr.,2001,131(3):989-993.
• [5]尹黎明,石元刚.大蒜燕麦及其复合物对高脂大鼠血脂水平和血液流变特性的影响[J].第三军医大学学报,2005,27(6):541-544.
• [6]Zhang X H,Lowe D,Giles P,et al.Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects[J].J-Nutr.,2001,131:1471-1478.
• [7]Liu L,Yeh Y Y.Water-soluble organosulfur compounds of garlic inhibit fatty acid and triglyceride synthesis in cultured rat hepatocytes[J].Lipids,2001,36:395-400.
• [8]Gupta N,Porter T D.Garlic and garlic derived compounds inhibit human squalene monooxygenase[J].J-Nutr.,2001,131:1662-1667.
• [9]Teranishi K,Apitz-Castro R,Robson S C,et al.Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative,ajoene[J].Xenotrans-plantation,2003,10(4):374-379.
• [10]Sendl A,Elbl G,Steinke B,et al.Comparative pharmacological investigations of Allium ursinum and Allium sativum[J].Planta Med.,1992,58:1-7.
• [11]Chang H S,Yamato O,Yamasaki M,et al.Modulatory influence of sodium 2-propenyl thiosulfate from garlic on cyclooxygenase activity in canine platelets:possible mechanism for the anti-aggregatory effect[J].Prostaglandins Leukot Essent Fatty Acids,2005,72(5):351-355.
• [12]李祖兰,张立文,丛玉隆,等.血浆钙离子浓度对血小板聚集的影响[J].军医进修学院学报,2012(3):39-40.
• [13]Qi R,Liao F,Inoue K,et al.Inhibition by diallyl trisulfide,agarlic component,of intracellular Ca2+mobilization without affecting inositol-1,4,5-triphosphate(IP3)formation in activated platelets[J].Biochem Pharmacol.,2000,60(10):1475-1483.
• [14]Kim-Park S,Ku D D.Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats[J].Clin Exp Pharmacol Physiol,2000,27:780-786.
• [15]聂晓敏,周玉杰,谢英,等.二烯丙基三硫化物涂层支架对冠状动脉损伤后血管壁内iNOS蛋白表达及NO水平的影响[J].第四军医大学学报,2006(11):975-977.
• [16]Dillon S A,Burmi R S,Lowe G M,et al.Antioxidant properties of aged garlic extract:an in vitro study incorporating human low density protein[J].Life Sci.,2003,72:1583-1594.
• [17]Dillon S A.Aged garlic extract as an antioxidant in cardiovascular disease[doctoral thesis][D].Liverpool John Moores University,Liverpool,UK,2002:32-35.
• [18]Ide N,Lau BHS.Garlic compounds minimise intracellular oxidative stress and inhibit nuclear factor-kB activation[J].J-Nutr.,2001,131:1020-1026.
• [19]Geng Z,Lau BHS.Aged garlic extract modulates glutathione redox cycle and superoxide dismutase activity in vascular endothelial cells[J].Phytother Res.,1997(11):54-56.
• [20]Dhawan V,Jain S.Effect of garlic supplementation on oxidised low density lipoproteins and lipid peroxidation in patients of essential hypertension[J].Mol Cell Biochem.,2004,266:109-115.
• [21]Dillion S A,Lowe G M,Billington D,et al.Dietary supplementation with aged garlic extract reduces plasma and urine concentrations of 8-iso-prostagalandin F(2alpha)in smoking and non-smoking men and women[J].J-Nutr.,2002,132:168-171.
• [22]Moriguchi T,Takasugi N,Itakura Y.The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes[J].J-Nutr.,2001,131:1016-1019.
• [23]Kempaiah R K,Srinivasan K.Influence of dietary spices on the fluidity of erythrocytes in hypercholesterolaemic rats[J].Br J Nutr.,2005,93:81-91.
• [24]Wu C C,Sheen L Y,Chen H W,et al.Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells[J].Food Chem Toxicol.,2001,39:563-569.
• [25]Li G,Shi Z,Jia H,et al.A clinical investigation on garlicin injection for the treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels[J].J Tradit Chin Med.,2000,20:243-246.
• [26]Breithaupt-Grogler K,Ling M,Boudoulas H,et al.Protective effect of chronic garlic intake on elastic properties of aorta in the elderly[J].Circulation,1997,96(8):2649-2655.
• [27]Kiesewetter H,Jung F,Jung E M,et al.Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack[J].Eur J Clin Pharmacol.,1993,45:333-336.
• [28]Anim-Nyame N,Sooranna S R,Johnson M R,et al.Garlic supplementation increases peripheral blood flow:a role for interleukin-6[J].J-Nutr Biochem.,2004,15:30-36.
• [29]Budoff M J,Takasu J,Flores F R,et al.Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy:apreliminary study[J].Prev Med.,2004,39:985-991.
• [30]许萌,武宇明.硫化氢心脏调节及保护作用的研究进展[J].河北医科大学学报,2009,30(2):197-200.
• [31]Benavides G A,Squadrito G L,Mills R W,et al.Hydrogen sulfide mediates the vasoactivity of garlic[J].PNAS,2007,104(46):17977-17982.