吴申懋,于华宁

• 1:乳业生物技术国家重点实验室
• 2:上海乳业生物工程技术研究中心
• 3:食品安全与营养协同创新中心
• 4:光明乳业股份有限公司乳业研究院

摘要(Abstract)：

桔霉素是一种聚酮类化合物,同时也是一种常见的真菌毒素,具有肾毒性和潜在的致癌致畸风险,是青霉属、曲霉属、红曲霉属等的次级代谢产物。桔霉素的存在严重影响了真菌发酵工程的安全性,对食品安全造成了严重的威胁。因此,如何减少或抑制桔霉素的产量已成为一个研究热点。近年来,随着分子生物学技术的发展,许多研究者对真菌次级代谢产物的生物合成及其调控进行了研究。文章重点介绍了桔霉素生物合成途径及相关基因的研究进展,为减少真菌发酵过程中桔霉素的产量,提供更优良的工业用菌株的参考和借鉴。

关键词(KeyWords)： 桔霉素;聚酮合酶;红曲霉

Abstract:

Keywords:

基金项目(Foundation): 上海优秀技术带头人项目(14XD1420300)

作者(Author): 吴申懋,于华宁

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