姜子涛,张清峰,李荣

• 1:天津商学院食品科学与工程系
• 2:天津商学院食品科学与工程系
• 3:天津商学院食品科学与工程系 天津300134
• 4:天津300134

摘要(Abstract)：

烯丙基异硫氰酸酯(AITC)是辣根中最重要的生物活性成分,具有很高的抗肿瘤和抗癌活性,研究了AITC与哌啶、吗啉、二乙胺等胺类化合物的反应动力学和光谱性质。AITC与胺反应转化为硫脲后,最大吸收峰强度有了极大的提高,摩尔吸光系数增加了十余倍;利用我们的发现,我们以光度法研究了该反应的动力学,证明该反应为二级反应,并求得了反应速率常数和反应活化能等参数;同时,讨论了反应机理。

关键词(KeyWords)： 烯丙基异硫氰酸酯;硫脲;吸收光谱;动力学

Abstract:

Keywords:

基金项目(Foundation): 天津市自然科学基金(043604511);; 天津市高校科技发展基金(20030905)资助课题

作者(Author): 姜子涛,张清峰,李荣

参考文献(References)：

• [1]林旭辉,李荣,姜子涛.辣根挥发油化学成分的研究[J].食品科学,2001,(22):73-75.
• [2]Guo Z,Smith T J,Wang E,Eklind K I,et al.Structure-activity relationships of arylalkylisothiocyanates for the inhibition of 4-(meth-ylnitrosoamino)-1-(3-pyridyl)-1-butano-nemetabolism and the modulation of xenobi-otic metabolizing enzymes in rats and mice[J].Carcinogenesis,1993,(14):1167-1173.
• [3]Morse M A,Zu H,Galati A J,et al.Dose-related inhibition by dietaryphenethyl iso-thiocyanate of esophageal tumorigenesis andDNA methylation induced by N-nitrosometh-ylbenzylaminein rats[J].Cancer Lett,1 9 9 3,(72):103-110.
• [4]Musk S R R,Smith T K,Johnson I T.On thecytotoxicity and genotoxicity of allyl and phe-nethyl isothiocyanates and their parent gluco-sinolates sinigrin and gluconasturtiin[J].Mutat Res,1995,(348):19-23.
• [5]Depree J A,Howard T M,Savage G P.Fla-vour and pharmaceutical properties of thevolatile sulphur compounds of Wasabi[J].FoodRes Int,1998,31(5):329-337.
• [6]Zhang Y,Talalay P.Anticarcinogenic activi-ties of organic isothiocyanates:Chemistry andmechanisms[J].Cancer Res,1 9 9 4,5 4(Supp.):1976s-1981s.
• [7]Zhang Y S,Wade K L,Prestera T,et al.Quantitative determination of isothiocyana-tes,dithiocarbamates,carbon disulfide,andrelated thiocarbonyl compounds by cyclocond-ensation with 1,2-benzenedithiol[J].AnalBiochem,1996,(239):160-167.
• [8]Chung F L,Jiao D,Getahun S M,et al.A uri-nary biomarker for uptake of dietary isoth-iocyanates in humans[J].Cancer Epidemiol,Biomarkers Prev,1998,(7):103-108.
• [9]Ye L X,Dinkova-Kostova A T,Wade K L,etal.Quantitative determination of dithiocarba-mates in human plasma,serum,erythrocytesand urine:pharmacokinetics of broccolisproutisothiocyanates in humans[J].Clinica Chi-mica Acta,2002,(316):43-53.
• [10]姜子涛,李荣.快速测定芥末油中异硫氰酸酯的含量[J].中国调味品,1992,(8):29-30.
• [11]宋世谟,王正烈,李文斌.物理化学(下)[M].高等教育出版社,1993,6.
• [12]夏海涛,许越,滕玉洁.物理化学实验[M].哈尔滨工业大学出版社,2003,5.
• [13]陈国珍,黄贤智,刘文远,等.紫外可见光分光光度法[M].原子能出版社,1983,5.
• [14]Chikkaputtaiah K S,Shankaranarayana M L,Natarajan C P.Volumetric determination ofallyl isothiocyanate in black mustard[J].TheFlavour Industry,1971,(10):591-593.