基于β-环糊精的姜黄素传递载体的研究进展Research Progress on Delivery Carrier of Curcumin Based on β-Cyclodextrins
陈帅,高彦祥
摘要(Abstract):
姜黄素是一种重要的天然色素和调味品,具有抗氧化、抗肿瘤、降血脂和预防老年痴呆等生理功能,但是水溶性差、理化性质不稳定、生物利用率低等缺点限制了其在食品和调味品中的应用。以β-环糊精为基质制备姜黄素的传递载体,可有效解决上述问题。文章结合国内外的研究文献,系统总结了β-环糊精的结构和性质、传递载体的制备方法、β-环糊精对姜黄素的运载及其在食品和调味品中的应用等方面的内容,最后对基于β-环糊精的姜黄素传递载体的现状进行了分析,并对其在食品和调味品中的发展前景进行了展望。
关键词(KeyWords): β-环糊精;姜黄素;传递载体;稳定性
基金项目(Foundation): “十三五”国家重点研发计划项目(2018YFD0400900);; 国家自然科学基金面上项目(31871842)
作者(Author): 陈帅,高彦祥
参考文献(References):
- [1]Pulido-Moran M,Moreno-Fernandez J,Ramirez-Tortosa C,et al.Curcumin and health[J].Molecules,2016,21(3):264-285.
- [2]Kakkar V,Kaur I P.Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural,biochemical and histopathological alterations in mice brain[J].Food and Chemical Toxicology,2011,49(11):2906-2913.
- [3]Vera-Ramirez L,Pérez-Lopez P,Varela-Lopez A,et al.Curcumin and liver disease[J].Biofactors,2013,39(1):88-100.
- [4]Yu H,Ke S,Dong L,et al.Development of a food-grade organogel with high bioaccessibility and loading of curcuminoids[J].Food Chemistry,2012,131(1):48-54.
- [5]叶霖,邓维,杨成,等.环糊精自组装:一种新型超分子材料的制备与应用[M].北京:北京理工大学出版社,2013.
- [6]孔丽.基于环糊精的超分子凝胶体系[D].济南:山东大学,2012.
- [7]Haiyee Z A,Saim N,Said M,et al.Characterization of cyclodextrin complexes with turmeric oleoresin[J].Food Chemistry,2009,114:459-465.
- [8]Zhong L,Bo C,Hu Y,et al.Complexation of resveratrol with cyclodextrins:solubility and antioxidant activity[J].Food Chemistry,2009,113(1):17-20.
- [9]Vertzoni M,Kartezini T,Reppas C,et al.Solubilization and quantification of lycopene in aqueous media in the form of cyclodextrin binary systems[J].International Journal of Pharmaceutics,2006,309(1-2):115-122.
- [10]Chao Y,Jin Z,Xu X,et al.Preparation and stability of the inclusion complex of astaxanthin with hydroxypropyl-β-cyclodextrin[J].Journal of Jiangsu University,2008,109(2):264-268.
- [11]Karathanos V T,Mourtzinos I,Yannakopoulou K,et al.Study of the solubility,antioxidant activity and structure of inclusion complex of vanillin withβ-cyclodextrin[J].Food Chemistry,2007,101(2):652-658.
- [12]Eid E E M, Abdul A B,Suliman F E O,et al.Characterization of the inclusion complex of zerumbone with hydroxypropyl-β-cyclodextrin[J].Carbohydrate Polymers,2011,83(4):1707-1714.
- [13]Mejri M,Bensouissi A,Aroulmoji V,et al.Hydration and selfassociation of caffeine molecules in aqueous solution:comparative effectsofsucroseandβ-cyclodextrin[J].Spectrochimica Acta Part A:Molecular&Biomolecular Spectroscopy,2009,73(1):6-10.
- [14]赵文静.基于环糊精新型超分子有机凝胶和功能分子的设计、合成与性质[D].济南:山东大学,2013.
- [15]李咏富.β-环糊精高分子聚合物的制备及其应用[D].北京:中国农业科学院,2015.
- [16]Chun J Y,Jo Y J,Bjrapha P,et al.Antimicrobial effect ofα-orβ-cyclodextrin complexes with trans-cinnamaldehyde against Staphylococcus aureus and Escherichia coli[J].Drying Technology,2015,33(3):377-383.
- [17]王雨雪,郭晓晖,梁强,等.环糊精包结增溶技术及其在食品工业中的应用研究进展[J].食品科学,2012(7):327-330.
- [18]Su J,Chen J,Li L,et al.Formation ofβ-cyclodextrin inclusion enhances the stability and aqueous solubility of natural borneol[J].Journal of Food Science,2012,77(6):658-664.
- [19]Jantarat C,Sirathanarun P,Ratanapongsai S,et al.Curcumin-hydroxypropyl-β-cyclodextrin inclusion complex preparationmethods:effectofcommonsolvent evaporation,freeze drying,and pH shift on solubility and stability of curcumin[J].Tropical Journal of Pharmaceutical Research,2014,13(8):1215-1223.
- [20]Li N,Wang N,Wu T,et al.Preparation of curcuminhydroxypropyl-β-cyclodextrininclusioncomplexby cosolvency-lyophilizationproceduretoenhanceoral bioavailability of the drug[J].Drug Development and Industrial Pharmacy,2018(6):1-24.
- [21]李艺,梅虎,赵春景,等.姜黄素环糊精分子包合物的构建和优化[J].食品与生物技术学报,2017,36(11):1197-1202.
- [22]Maria D N,Mishra S R,Wang L,et al.Water-soluble complex of curcumin with cyclodextrins:enhanced physical properties for ocular drug delivery[J].Curr Drug Deliv,2017,14(6):875-886.
- [23]Marcolino V A,Zanin G M, Durrant L R,et al.Interaction of curcumin and bixin withβ-cyclodextrin:complexation methods, stability, and applications in food[J].Journal of Agricultural and Food Chemistry,2011,59(7):3348-3357.
- [24]Al Hagbani T,Nazzal S.Curcumin complexation with cyclodextrins by the autoclave process:method development and characterization of complex formation[J].International Journal of Pharmaceutics,2017,520(1-2):173-180.
- [25]Ghanghoria R, Kesharwani P, Agashe H B,et al.Transdermal delivery of cyclodextrin-solubilized curcumin[J].Drug Delivery and Translational Research,2013(3):272-285.
- [26]Zetzl A K, Marangoni A G.Structured oils and fats(organogels)as food ingredient and nutraceutical delivery systems[J].Encapsulation Technologies and Delivery Systems for Food Ingredients and Nutraceuticals,2012,84(10):392-411.
- [27]Li Z L,Hao A Y,Hao J C.Formation of heat-triggered supramolecular organogel in whichβ-cyclodextrin as sole gelator[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2014,441:8-15.
- [28]Yan E,Hao X,Cao M,et al.Preparation and characterization of carboxymethyl chitosan hydrogel[J].Pigment&Resin Technology,2016,45(4):246-251.
- [29]Cesteros L C,González-teresa R,Katime I.Hydrogels ofβ-cyclodextrin crosslinked by acylated poly(ethylene glycol):synthesis and properties[J].European Polymer Journal,2009,45(3):674-679.
- [30]Xu J,Li X,Sun F.Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release[J].Acta Biomaterialia,2010,6(2):486-493.
- [31]Rachmawati H, Edityaningrum C A, Mauludin R.Molecular inclusion complex of curcumin-β-cyclodextrin nanoparticle to enhance curcumin skin permeability from hydrophilic matrix gel[J].Aaps Pharmscitech,2013,14(4):1303-1312.
- [32]Zhang Y.Enhancing antidepressant effect of poloxamer/chitosanthermosensitivegelcontainingcurcumincyclodextrin inclusion complex[J].International Journal of Polymer Science,2018,5(2):6-14.
- [33]Serri C,ArgiròM,Piras L,et al.Nano-precipitated curcumin loaded particles:effect of carrier size and drug complexation with(2-hydroxypropyl)-β-cyclodextrin on their biological performances[J].International Journal of Pharmaceutics,2017,520(1-2):21-28.
- [34]Hadi B J,Sanagi M M, Aboul-Enein H Y,et al.Microwave-assisted extraction of methylβ-cyclodextrincomplexed curcumin from turmeric rhizome oleoresin[J].Food Analytical Methods,2015,8(10):2447-2456.
- [35]Karpkird T,Khunsakorn R,Noptheeranuphap C,et al.Inclusion complexes and photostability of UV filters and curcumin withβ-cyclodextrin polymers:effect on crosslinkers[J]. JournalofInclusionPhenomenaand Macrocyclic Chemistry,2018,91(1-2):37-45.
- [36]Mohan P R K,Sreelakshmi G,Muraleedharan C V,et al.Water soluble complexes of curcumin with cyclodextrins:characterization by FT-Raman spectroscopy[J].Vibrational Spectroscopy,2012,62:77-84.
- [37]Yallapu M M,Jaggi M,Chauhan S C.β-Cyclodextrincurcumin self-assembly enhances curcumin delivery in prostate cancer cells[J].Colloids and Surfaces B:Biointerfaces,2010,79(1):113-125.
- [38]Chen J,Qin X,Zhong S,et al.Characterization of curcumin/cyclodextrin polymer inclusion complex and investigation on its antioxidant and antiproliferative activities[J].Molecules,2018,23(5):1179-1191.
- [39]Mangolim C S, Moriwaki C, Nogueira A C,et al.Curcumin-β-cyclodextrininclusioncomplex:stability,solubility,characterisation by FT-IR,FT-Raman,X-ray diffraction and photoacoustic spectroscopy, and food application[J].Food Chemistry,2014,153:361-370.